The high prevalence of cardiovascular diseases demands a reliable and sensitive risk assessment technique. In order to develop a fast and label-free immunosensor for C-reactive protein, a risk factor for this condition, anti-CRP antibodies were physically adsorbed to the hydrogen -terminated surface of nanocrystalline diamond. An Enzyme-Linked ImmunoSorbent Assay reference technique showed that this was a suitable substrate for antibody-antigen recognition reactions. Electrochemical Impedance Spectroscopy was used to electronically detect CRP recognition. The specificity of the immunosensor was demonstrated by incubation (...) with CRP and plasminogen as reference molecule. A different impedance behavior was observed in real-time after CRP addition as compared to plasminogen addition: the impedance increased only during CRP incubation. Fitting the data showed that this corresponded with a decrease in capacitance of the molecular layer due to its increased thickness by specific CRP recognition. Sensitivity experiments in real-time showed a clear discrimination between 1 μM, 100 nM, and 10 nM of CRP after 10 min at 100 Hz. Since, 10 nM of CRP was still clearly distinguishable from buffer solution, our CRP-directed immunosensor prototype reaches a sensitivity that is within the physiologically relevant concentration range of this biomarker in healthy controls and CVD patients. Moreover, this prototype displayed real-time discriminating power between spiked and unspiked serum, and thus also shows its applicability in this biological matrix. © 2011 Elsevier B.V. All rights reserved. (shrink)

This study aimed to explore stakeholders’ perspectives on the ethical considerations for returning individual pharmacogenomics research results to people living with HIV. A qualitative approach to investigation involved five focus group discussions with 30 Community representatives, 12 key informant interviews with researchers, and 12 in-depth interviews with research ethics committee members. In total, 54 stakeholders who were involved in pharmacogenomics research and HIV treatment and care contributed to the data collection between September 2021 and February 2022. The study explored five (...) prominent themes: (i) defining the nature of research results to return to participants; (ii) preparing research participants to receive their results; (iii) obtaining informed consent for the return of results; (iv) opinions on health personnel to return the results to participants; and (v) opinions on how research results should be communicated to participants. Respondents identified various strategies for the return of individual results with minimal ethical risks including the setting up of a diverse and independent committee to undertake a risk-benefit assessment based on local context; ongoing discussions about the possible kinds of results and their implications throughout the study; and employing genetic counsellors to communicate results to participants. The strategies identified in this study should be further studied and independently verified. (shrink)

The coming of bioethics to Singapore / W. Calvin Ho and Sylvia S.N. Lim -- The impact of the bioethics advisory committee on the research community in Singapore / Charmaine K.M. Chan and Edison T. Liu -- Engaging the public : the role of the media / Chang Ai-Lien and Judith Tan -- Confucian trust and the biomedical regulatory framework in Singapore / Anh Tuan Nuyen -- The clinician-researcher : a servant of two masters? / Alastair V. Campbell, Jacqueline (...) Chin, and Teck Chuan Voo -- The US model for oversight of human stem cell research / Lindsay Parham and Bernard Lo -- Genetics and stem cell research : models of international policy-making / Bartha Maria Knoppers, Emily Kirby and Rosario Isasi -- Public engagement and bioethics commissions / Thomas H. Murray and Ross S. White -- Norm-making on human-animal chimeras and hybrids in Singapore, the United Kingdom and the international domain / W. Calvin Ho and Martin Bobrow -- How will future bioethical issues engage Singapore? / John Elliott. (shrink)

Для широкого круга читателей (слушателей, аспирантов, преподавателей) интересующихся данной проблемой.

We present a novel variant of decision making based on the mathematical theory of separable Hilbert spaces. This mathematical structure captures the effect of superposition of composite prospects, including many incorporated intentions, which allows us to describe a variety of interesting fallacies and anomalies that have been reported to particularize the decision making of real human beings. The theory characterizes entangled decision making, non-commutativity of subsequent decisions, and intention interference. We demonstrate how the violation of the Savage’s sure-thing principle, known (...) as the disjunction effect, can be explained quantitatively as a result of the interference of intentions, when making decisions under uncertainty. The disjunction effects, observed in experiments, are accurately predicted using a theorem on interference alternation that we derive, which connects aversion-to-uncertainty to the appearance of negative interference terms suppressing the probability of actions. The conjunction fallacy is also explained by the presence of the interference terms. A series of experiments are analyzed and shown to be in excellent agreement with a priori evaluation of interference effects. The conjunction fallacy is also shown to be a sufficient condition for the disjunction effect, and novel experiments testing the combined interplay between the two effects are suggested. (shrink)

Wedin considers the relation between the ontological commitment in the Categories and the semantical theory of underlying ontological configurations for standard categorical statements. According to Wedin, Aristotle's fourfold division of beings, which divides things according to whether they are, or are not, said of, and/or present in a subject, is a meta‐ontology that is concerned with beings per se, i.e. the fundamental things that are. Wedin explains that the primacy of c‐substance involves an asymmetry in the relation between c‐substance and (...) everything else, or between the substantial and the nonsubstantial. This is because there is an ontological dependence of non‐substances, and also of secondary substances, on substances: everything is either said of, or in, primary substance. The argument of this chapter, then, is that the world of the Categories is a world of individuals: all ontological relations needed for semantics can be accommodated by appeal to individuals only. (shrink)

Wedin argues that Aristotle makes form the substance of c‐substances because it is the essence of the c‐substance. Much of this chapter consists of a careful examination of a passage in Metaphysics Zeta 4, which Wedin calls the ‘New Primacy Passage’, that is crucial to Wedin's overall thesis, because here Aristotle appeals to a notion of definitional primacy, as opposed to the ontological primacy of the Categories. Z.4 focuses on this claim that form must be essence: Wedin argues that essence (...) is a certain kind of form, a form of a genus ; this does not mean ‘species’, as some commentators have thought. This is because the species is a combination of form and matter, whereas the genous eidos, Wedin argues, is the formal part only of the definition that applies to the thing. On Wedin's account, Aristotle introduces the notion of explanatory primacy of form in Z.4. (shrink)

Wedin offers an interpretation of Metaphysics Zeta 13, a very important and difficult chapter, where Aristotle apparently denies that substance is a universal, having, on most accounts, already claimed that form is substance, and that form is a universal. This interpretation of the argument of Z.13, Wedin argues, threatens the possibility of attaining a definition of substance, and places in doubt what has gone before in the treatise. According to Wedin, what Aristotle is concerned with in Z.13 is not the (...) denial that substance is a universal but rather with the denial that anything predicated universally of a c‐substance is the substance‐of the c‐substance, which Wedin calls ‘Weak proscription’. In Wedin's account of Z.13, then, Aristotle is continuing to pursue issues first raised in Z.10–11 that have to do with the relations between form and definition, and form and the universal. Wedin also argues that the dilemma at the conclusion of Z.13, regarding the definability of substance, is resolved in Z.16, with the notion of ‘Dual Complexity’, according to which the parts of a form exist potentially in the form, just as the parts of the c‐substance exist potentially in the c‐substance. (shrink)

Wedin addresses the debate over whether nonsubstantial individuals, that inhere in a subject but are not said of a subject, i.e. accidents, such as the pallor of Socrates, are nonrecurring particulars or a kind of determinate universal. Wedin examines the secondary literature on this topic and divides it into two schools of thought, determined by the contributions of J.L. Ackrill and G.E.L. Owen. According to Ackrill, individuals in non‐substance categories are particular to the substance they are in; Owen critiques Ackrill's (...) view, and proposes that these items can recur in more than one subject and hence are a sort of universal. Wedin finds Owen's thesis unsatisfactory, even after supplementing it with an improved version due to Michael Frede; instead, Wedin argues for a revised version of Ackrill's interpretation of nonsubstantial individuals as nonrecurrent particulars. According to Wedin, Aristotle is committed to individuals only—e.g. to Socrates and to the particular bit of pallor in him: this conclusion has an important bearing on the ontological status of individuals and on the primacy of substance to nonsubstantial items. (shrink)

Wedin considers the problem of the compatibility of the Categories account of primary substance with the theory of substantial form of the Metaphysics. Wedin collects from the secondary literature the most important arguments for incompatibilism, and offers some proposals for restoring their harmony. While admitting the evident differences in the way Aristotle treats the question of substance in each treatise, Wedin is keen to argue that these differences are not sufficient to conclude that the treatises are incompatible. Wedin singles out (...) for particular attention, and criticism, Michael Frede and Gunther Patzig's account of Metaphysics Zeta, according to which the primary substance of the Metaphysics and the basic subject of predications is the form. Wedin considers two ‘philosophical’ arguments and one ‘Aristotelian’ argument for the subjecthood of forms, and argues that the textual evidence does not support the claim that form is the subject of accidents. (shrink)

Chapters 10 and 11 are critical to the argument of Metaphysics Zeta: these chapters are concerned with the purification of form. Z.10 introduces the apparatus of part and whole and consists of an argument to the end that form and its parts have priority over the other internal structural components of c‐substances, i.e. matter and the compound of form and matter; while in Z.11 Aristotle argues that form and its parts cannot involve any admixture of matter. Wedin argues that the (...) causal role of form presupposes its purity: if form is to explain why a certain portion of matter constitutes a c‐substance of a given kind, then matter—whether this latter is understood as functional, or remnant matter—cannot already be contained in the form. This is the ‘purity thesis’, as Wedin calls it: matter cannot be included in the definitions of natural organisms, Wedin points out, because that would make the explanandum a part of the principle that explains it. Wedin also argues that form must be sufficiently complex to provide definitions of the natures of particular compounds, which are complex, even though form itself is a kind of universal. (shrink)

In the Metaphysics, Aristotle often says that ‘form is substance’: in this chapter, Wedin argues that ‘substance’ in this context means the ‘substance‐of’ c‐substances. Wedin begins by examining Aristotle's use, and retention, of the framework of the Categories in Metaphysics Zeta, before turning to discuss Z.3, which is crucial to understanding the relation between the Categories and Metaphysics theories of substance, because it is usually thought that here Aristotle departs from the substance of the Categories. Wedin denies that Z.3 involves (...) a rejection of the Categories subjecthood criterion for primary substance: Aristotle rejects only the claim that one thing is the substance of another simply if it is the primary underlying subject of the other. Wedin argues that in Z.3 Aristotle introduces the idea of the ‘substance‐of’ a thing, and identifies as candidates for the substance of c‐substances the internal structural components form, matter, and the compound of form and matter. (shrink)

Wedin discusses Aristotle's claims in Metaphysics Zeta 6 that the essence of a thing is to be sought among its per se attributes, and that each thing that is primary and spoken of per se, e.g. primary substance, is the same as its essence. Wedin argues that the Zeta 6 Thesis, i.e. that the essence of a thing is the thing's immediate essence, is a crucial requirement of the explanatory role of essence as the substance of c‐substances. According to Wedin, (...) Aristotle introduces this requirement in order to establish that a thing's essence cannot depend on another essence. Form must be the essence; if form cannot explain the nature of the thing of which it is the form, there would be the threat of a regress of explanatory forms. At the end of the chapter, Wedin considers the problem that the identity of a thing and its essence is a requirement that can be met by non‐substance items, but he denies that this leads to a dilution of the conception of substance. (shrink)

This essay explores the aspects of the Aristotelian psuchē that accounts for its contemporary appeal. The poverty of the notion of the mind is discussed. The superiority of the psuchē over the mind is emphasized.

In this paper, we take a fresh look at three Popperian concepts: riskiness, falsifiability, and truthlikeness of scientific hypotheses or theories. First, we make explicit the dimensions that underlie the notion of riskiness. Secondly, we examine if and how degrees of falsifiability can be defined, and how they are related to various dimensions of the concept of riskiness as well as the experimental context. Thirdly, we consider the relation of riskiness to truthlikeness. Throughout, we pay special attention to probabilistic theories (...) and we offer a tentative, quantitative account of verisimilitude for probabilistic theories. (shrink)

The glorious anniversary of the great victory of the Soviet people and their heroic armed forces over the most aggressive armies of international imperialism provides a perspective that makes it possible to see the importance of this feat on the scale of world history, in the vivid light of the favorable influence it has exercised on all the subsequent development of sociopolitical processes on earth.